GILUPI CellCollector
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Circulating tumor cells
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GILUPI CellCollector


“A novel method for the in vivo isolation of circulating tumor cells from peripheral blood of cancer patients using a functionalized and structured medical wire”
Saucedo-Zeni N, Mewes S, Niestroj R, Gasiorowski L, Murawa D, Nowaczyk P, Tomasi T, Weber E, Dworacki G, Morgenthaler NG, Jansen H, Propping C, Sterzynska K, Dyszkiewicz W, Zabel M, Kiechle M, Reuning U, Schmitt M, Lücke K.

Int J Oncol. 2012 Oct;41(4):1241-50
doi: 10.3892/ijo.2012.1557
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“Enumeration and molecular characterization of tumor cells in lung cancer patients using a novel in vivo device for capturing circulating tumor cells”
Gorges TM, Penkalla N, Schalk T, Joosse S, Riethdorf S, Tucholski J, Lucke K, Wikman H, Jackson SM, Brychter N, von Ahsen O, Schumann C, Krahn T, Pantel K.

Clin Cancer Res. 2015 Dec 14. pii: clincanres.1416.2015.
doi: 10.1158/1078-0432.CCR-15-1416

1 "The Use of a New CellCollector to Isolate Circulating Tumor Cells from the Blood of Patients with Different Stages of Prostate Cancer and Clinical Outcomes - A Proof-of-Concept Study"
Theil G, Fischer K, Weber E, Medek R, Hoda R, Lücke K, Fornara P.

PLoS One. 2016 Aug 1;11(8):e0158354.
1 “A comparison of CellCollector with CellSearch in patients with neuroendocrine tumours”
Endocr Relat Cancer. 2016 Oct;23(10):L29-32.

Epub 2016 Aug 12. No abstract available.
doi: 10.1530/ERC-16-0201.
1 “Circulating tumor cells in patients with breast tumors were detected by a novel device: a multicenter, clinical trial in China”
Li JB, Geng CZ, Yan M, Wang YS, Ouyang QC, Yin YM, Wu LN, He J, Jiang ZF.
Zhonghua Yi Xue Za Zhi.

2017 Jun 27;97(24):1857-1861.
doi: 10.3760/cma.j.issn.0376-2491.2017.24.003.

“Improved detection of circulating tumor cells in non-metastatic high-risk prostate cancer patients.”
Kuske A, Gorges TM, Tennstedt P, Tiebel AK, Pompe R, Preißer F, Prues S, Mazel M, Markou A, Lianidou E, Peine S, Alix-Panabières C, Riethdorf S.

Sci Rep. 2016 Dec 21;6:39736.

1 “Enumeration and molecular characterization of circulating tumor cell using an in vivo capture system in squamous cell carcinoma of head and neck.”
Zhang H, Gong S, Liu Y, Liang L, He S, Zhang Q, Si M, Yu Z.

Chin J Cancer Res. 2017 Jun; 29(3):196-203
doi: 10.21147/j.issn.1000-9604.2017.03.05.
1 “Using the New CellCollector to Capture Circulating Tumor Cells from Blood in Different Groups of Pulmonary Disease: A Cohort Study.”
He Y, Shi J, Shi G, Xu X, Liu Q, Liu C, Gao Z, Bai J, Shan B

Sci Rep. 2017 Aug 25;7(1):9542.
doi: 10.1038/s41598-017-09284-0.
1 “In-vivo isolation of circulating tumor cells in non-small cell lung cancer patients by CellCollector.”
Gasiorowski L, Dyszkiewicz W, Zielinski P.

Neoplasma. 2017 Sep 12.
doi: 10.4149/neo_2017_618.
1 “Multiplex Gene Expression Profiling of In Vivo Isolated Circulating Tumor Cells in High-Risk Prostate Cancer Patients.”
Markou A, Lazaridou M, Paraskevopoulos P, Chen S, ?wierczewska M, Budna J, Kuske A, Gorges TM, Joosse SA, Kroneis T, Zabel M, Sedlmayr P, Alix-Panabières C, Pantel K, Lianidou ES.

Clin Chem. 2017 Nov 9.
pii: clinchem.2017.275503. doi: 10.1373/clinchem.2017.275503.
1 “In Situ Detection and Quantification of AR-V7, AR-FL, PSA, and KRAS Point Mutations in Circulating Tumor Cells.”
El-Heliebi A, Hille C, Laxman N, Svedlund J, Haudum C, Ercan E, Kroneis T, Chen S, Smolle M, Rossmann C, Krzywkowski T, Ahlford A, Darai E, von Amsberg G, Alsdorf W, König F, Löhr M, de Kruijff I, Riethdorf S, Gorges TM, Pantel K, Bauernhofer T, Nilsson M, Sedlmayr P

Clin Chem. 2018
Jan 4. pii: clinchem.2017.281295. doi: 10.1373/clinchem.2017.281295.
1 “Characterization of Tumor Cells Using a Medical Wire for Capturing Circulating Tumor Cells: A 3D Approach Based on Immunofluorescence and DNA FISH.”
Gallerani G, Cocchi C, Bocchini M, Piccinini F, Fabbri F

Vis Exp. 2017
Dec 21;(130). doi: 10.3791/56936.

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Since then, the GILUPI CellCollector® technology has been mentioned in other papers on circulating tumor cells:


"Catch and Release: rare cell analysis from a functionalised medical wire"
Chen S, El-Heliebi A, Tauber G, Langsenlehner T, Pötscher M, Kashofer K, Czy? ZT, Polzer B, Riethdorf S, Kuske A, Leitinger G, Pantel K, Kroneis T, Sedlmayr P.

Sci Rep. 2017 Feb 24;7:43424.
doi: 10.1038/srep43424.


"Highly Selective Capture Surfaces on Medical Wires for Fishing Tumor Cells in Whole Blood"
Scherag FD, Niestroj-Pahl R, Krusekopf S, Lücke K, Brandstetter T, Rühe J.

Anal Chem. 2017 Feb 7;89(3):1846-1854.

Epub 2017 Jan 12.

1 "Biology, detection, and clinical implications of circulating tumor cells"
Joosse SA, Gorges TM, Pantel K.

EMBO Mol Med. 2014 Nov 14. pii: e201303698.

1 "Challenges in circulating tumour cell research"
Alix-Panabières C, Pantel K.

Nat Rev Cancer. 2014 Sep;14(9):623-31.

1 "Molecular analysis of circulating tumour cells —biology and biomarkers."
Krebs MG, Metcalf RL, Carter L, Brady G, Blackhall FH, Dive C.

Nat Rev Clin Oncol. 2014 Mar;11(3):129-44.

1 467 Verification of a functionalized structured medical wire for the isolation of circulating tumor cells (CTC) in patients with renal cell carcinoma.
Theil G, Wencker A, Fischer K, Pini G, Lücke K, Fornara P.

J. Urol. 2013 May;189 (4S, Supplement):192. Abstract 467.

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1 Circulating tumor cells as therapy-related biomarkers in cancer patients.

Gorges TM, Pantel K.

Cancer Immunol Immunother. 2013 May;62(5):931-9.
doi: 10.1007/s00262-012-1387-1
1 Circulating tumor cells: liquid biopsy of cancer.

Alix-Panabières C, Pantel K.

Clin Chem. 2013 Jan;59(1):110-8,
doi: 10.1373/clinchem.2012.194258
1 Detection methods of circulating tumor cells.

Pantel K, Alix-Panabières C.

J Thorac Dis. 2012 Oct;4(5):446-7.
doi: 10.3978/j.issn.2072-1439.2012.08.15
1 "Considerations in the development of circulating tumor cell technology for clinical use"

Parkinson et al., J Transl Med. 2012 Jul 2;10:138.
doi: 10.1186/1479-5876-10-138


So far, GILUPI has presented clinical results from GILUPI CellCollector® applications at numerous national and international meetings and exhibitions.
See Previous Events

1st in vivo CTC isolation CE approval worldwide >>
Application possible in all cancer indications, clinical results available for prostate, lung, breast and colorectal cancer >>
Proven safety and functionality >>
70% CTC detection rate >>
CTC detection in all cancer stages >>
GILUPI presentations of clinical results at the following meetings & exhibitions:
DGU (Dresden)
ECCO (Amsterdam)
EAU (Stockholm)
ACTC (Athens)
ISMRC (Paris
ASCO (Chicago)
EBCC (Vienna)
ELCC (Geneva)
DKK (Berlin)
MEDICA (Düsseldorf)