The revolutionary in vivo technology of the GILUPI CellCollector® has been published in July 2012 in the International Journal of Oncology.
A novel method for the in vivo isolation of circulating tumor cells from peripheral blood of cancer patients using a functionalized and structured medical wire
Saucedo-Zeni N, Mewes S, Niestroj R, Gasiorowski L, Murawa D, Nowaczyk P, Tomasi T, Weber E, Dworacki G, Morgenthaler NG, Jansen H, Propping C, Sterzynska K, Dyszkiewicz W, Zabel M, Kiechle M, Reuning U, Schmitt M, Lücke K.
Int J Oncol. 2012 Oct;41(4):1241-50
Another scientific publication of the GILUPI CellCollector® technology has been released in December 2016 in the journal “Clinical Cancer Research“:
“Enumeration and molecular characterization of tumor cells in lung cancer patients using a novel in vivo device for capturing circulating tumor cells”
Gorges TM, Penkalla N, Schalk T, Joosse S, Riethdorf S, Tucholski J, Lucke K, Wikman H, Jackson SM, Brychter N, von Ahsen O, Schumann C, Krahn T, Pantel K.
Clin Cancer Res. 2015 Dec 14. pii: clincanres.1416.2015.
In August 2016 a paper was published describing isolation of circulating tumor cells from blood of prostate cancer patients with GILUPI CellCollector®:
“The Use of a New CellCollector to Isolate Circulating Tumor Cells from the Blood of Patients with Different Stages of Prostate Cancer and Clinical Outcomes - A Proof-of-Concept Study”
Theil G, Fischer K, Weber E, Medek R, Hoda R, Lücke K, Fornara P.
PLoS One. 2016 Aug 1;11(8):e0158354.
doi: 10.1371/journal.pone.0158354. eCollection 2016.
In October 2016 a published scientific paper demonstrated for the first time circulating tumor cell isolation from blood of neuroendocrine tumor patients with GILUPI CellCollector®:
“A comparison of CellCollector with CellSearch in patients with neuroendocrine tumours”
Endocr Relat Cancer. 2016 Oct;23(10):L29-32.
doi: 10.1530/ERC-16-0201. Epub 2016 Aug 12. No abstract available.
A further publication describing detection of circulating tumor cells from breast cancer patients with GILUPI CellCollector® was published in June 2017. Article in Chinese; Abstract available in English:
“Circulating tumor cells in patients with breast tumors were detected by a novel device: a multicenter, clinical trial in China”
Li JB, Geng CZ, Yan M, Wang YS, Ouyang QC, Yin YM, Wu LN, He J, Jiang ZF.
Zhonghua Yi Xue Za Zhi. 2017 Jun 27;97(24):1857-1861.
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Since then, the GILUPI CellCollector® technology has been mentioned in other papers on circulating tumor cells:
" ? Highly Selective Capture Surfaces on Medical Wires for Fishing Tumor Cells in Whole Blood"
Scherag FD, Niestroj-Pahl R, Krusekopf S, Lücke K, Brandstetter T, Rühe J.
Anal Chem. 2017 Feb 7;89(3):1846-1854.
doi:10.1021/acs.analchem.6b04219. Epub 2017 Jan 12.
||"Biology, detection, and clinical implications of circulating tumor cells"
Joosse SA, Gorges TM, Pantel K.
EMBO Mol Med. 2014 Nov 14. pii: e201303698.
||"Challenges in circulating tumour cell research"
Alix-Panabières C, Pantel K.
Nat Rev Cancer. 2014 Sep;14(9):623-31.
||"Molecular analysis of circulating tumour cells —biology and biomarkers."
Krebs MG, Metcalf RL, Carter L, Brady G, Blackhall FH, Dive C.
Nat Rev Clin Oncol. 2014 Mar;11(3):129-44.
||467 Verification of a functionalized structured medical wire for the isolation of circulating tumor cells (CTC) in patients with renal cell carcinoma.
Theil G, Wencker A, Fischer K, Pini G, Lücke K, Fornara P.
J. Urol. 2013 May;189 (4S, Supplement):192. Abstract 467.
||Circulating tumor cells as therapy-related biomarkers in cancer patients.
Gorges TM, Pantel K.
Cancer Immunol Immunother. 2013 May;62(5):931-9.
||Circulating tumor cells: liquid biopsy of cancer.
Alix-Panabières C, Pantel K.
Clin Chem. 2013 Jan;59(1):110-8,
||Detection methods of circulating tumor cells.
Pantel K, Alix-Panabières C.
J Thorac Dis. 2012 Oct;4(5):446-7.
||"Considerations in the development of circulating tumor cell technology for clinical use"
Parkinson et al., J Transl Med. 2012 Jul 2;10:138.
So far, GILUPI has presented clinical results from GILUPI CellCollector® applications at numerous national and international meetings and exhibitions.
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